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Lu S et al. (2020). "CDD/SPARCLE: the conserved domain database in 2020.", Nucleic Acids Res. 48 (D1) :D265-D268. pfam02701 (PSSM ID: 397014): Conserved Protein Domain Family zf-Dof, The Dof domain is a zinc finger DNA-binding domain, that shows resemblance to the Cys2 zinc finger.
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The OTU family of cysteine proteases use a conserved cysteine and histidine, and in most cases an aspartate, as the catalytic triad. OTU domains typically function as deubiquitinases (DUBs)/ubiquitin thiolesterases (EC 3.4.19.12) that catalyze the thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by …
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Citing CDD. Lu S et al. (2020). "CDD/SPARCLE: the conserved domain database in 2020.", Nucleic Acids Res. 48 (D1) :D265-D268. pfam10050 (PSSM ID: 431017): Conserved Protein Domain Family DUF2284, Members of this family of metal-binding hypothetical bacterial proteins have no known function.
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16262624 389 A L L I A H D R I S L F D E K Q 404 Sinorhizobium meliloti 20089680 86 T H D V I G D W K E I L K G N I 101 Methanosarcina acetivorans C2A 20091970 107 C R D A L K L L K-----115 Methanosarcina acetivorans C2A 20092534 107 C R N A L K M L K D M-----117 Methanosarcina acetivorans C2A 2833560 97 A M K I L E …
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Cytochrome c oxidase subunit Vb. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of prokaryotes. It catalyzes the reduction of O2 and simultaneously pumps …
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PAZ domain. This domain is named PAZ after the proteins Piwi Argonaut and Zwille. This domain is found in two families of proteins that are involved in post-transcriptional gene silencing. These are the Piwi family and the Dicer family, that includes the Carpel factory protein. The function of the domains is unknown but has been …
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The catalytic domain of CAMK family Serine/Threonine Kinases. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including …
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This group contains the catalytic core domain of RdRp of RNA viruses belonging to the family Kitaviridae, order Martellivirales. The family Kitaviridae is composed of five recognized species among the three genera: Blueberry necrotic ring blotch virus and Tea plant necrotic ring blotch virus (genus Blunervirus); Citrus leprosis virus C and Citrus …
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MYM-type zinc fingers were identified in MYM family proteins. Human protein ZMYM3 is involved in a chromosomal translocation and may be responsible for X-linked retardation in XQ13.1. ZMYM2 is also involved in disease. In myeloproliferative disorders it is fused to FGF receptor 1; in atypical myeloproliferative disorders it is rearranged.
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Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs …
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19112076 233 I Y K T E T K E f E G v i r n k h r k D A V D V T E C V G 261 fission yeast 14601585 186 -W K P V V L P-T P-----A G L L L A V K T A 204 Aeropyrum pernix 19551427-----Corynebacterium glutamicum ATCC 13032 15805630 531 R R E R V I L A-----T K H A I P G R S K 548 Deinococcus radiodurans 15840664 197 R L T P A L V P l …
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Prostacyclin synthase (CYP8A1) catalyzes the isomerization of prostaglandin H2 to prostacyclin (or prostaglandin I2), a potent mediator of vasodilation and anti-platelet aggregation. This family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large ...
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