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IC 50 values of 39±10, 83±10 and 280±12 μM were determined at 125, 500 and 1000 nM of trimeric MLL complex respectively. IC 50 values for WDR5-0103 and the tetrameric MLL complex were significantly higher and were not calculated owing to incomplete fitting. However, the inhibitory effect of WDR5-0103 is more pronounced as …
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Purity (along with compound The effect of WDR5-0103 on the activity of the MLL complex identity) was assessed further by NMR spectroscopy (500 MHz), was tested in at least duplicate at three different concentrations and compounds failing to meet the standard were subsequently of trimeric (125, 500 and 1000 nM) and tetrameric (10, 50 purified by ...
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Focusing to 30 nm for 19.5 keV has been demonstrated at APS beamlines with a WSi2/Si MLL having 728 layers made at the APS. These same techniques were used to achieve a partial linear zone plate structure having a 5-nm outer most zone width and consisting of 1588 total layers as discussed below.
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andfig.S1).Insurvivalassays,MLL-AF9 and MLL-ENL cells were sensitive and killedbybirinapant,whereasNup98-HoxA9 and HoxA9 + Meis1 leukemias were resist-ant(Fig.1B).CelldeathofMLL-ENLand MLL-AF9 was induced by 250 nM biri-napant, although 50 nM was sufficient toinducedcIAP1depletion(Fig.1C).This may indicate that antagonism …
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Can the optics get to 1-nm?. Hanfei Yan NSLS-II, Brookhaven National Laboratory. Collaborators. Multilayer-Laue-Lens (MLL) deposition Al Macrander 1 Chian Liu 1 Ray Conley 1 MLL characterization and focusing measurement Brian Stephenson 2,3 Hyon Chol Kang 2,3 Theoretical Modeling Slideshow...
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Targeting the menin-MLL protein-protein interaction is being pursued as a new therapeutic strategy for the treatment of acute leukemia carrying MLL-rearrangements (MLLr leukemia). Herein, we report M-1121, a covalent and orally active inhibitor of the menin-MLL interaction capable of achieving complete and persistent tumor regression.
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VTP50469 rapidly suppressed the gene expression program in MLL-rearranged cell lines and showed activity at low nM concentrations in various cellular contexts. Interestingly, the kinetics underlying the suppression of gene expression were more rapid than that seen with some other epigenetic therapies such as DOT1L inhibitors.
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A milliliter is a unit of volume in the Metric System. The symbol for milliliter is mL and the International spelling for this unit is millilitre. The base unit for a milliliter is liter and the prefix is milli. The prefix milli is derived from the Latin mille meaning one thousand and is symbolized as m in the Metric System. Milli denotes a factor of one thouh (1/1000th) …
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Massive localized lymphedema (MLL) is a rare condition observed in the morbidly obese populations. The epidemiology of MLL is currently unknown, but due to increasing prevalence of obesity worldwide, 1, 2 its incidence is expected to rise. MLL is associated with disturbance of efferent lymphatic flow possibly due to extensive adipose …
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After its translation, wild-type MLL1 is proteolytically cleaved by the enzyme taspase-1 (19, 20).The resulting 320-kDa N-terminal fragment (MLL-N) contains all domains except the transcriptional activation domain and the SET domain, both of which are retained by the 180-kDa C-terminal fragment (MLL-C).MLL-N and MLL-C normally associate with …
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The MLL Leukemia. Human leukemias with an MLL translocation account for >50% of acute lymphoblastic leukemia (ALL) in infants less than 6 mon of age and for up to 10% of both de novo acute lymphoblastic and acute myeloid leukemia (AML) in children and adults. 14 Furthermore, MLL translocations are also observed in ∼33% of therapy-related ...
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Even though most cases in all 4 groups were sensitive to obatoclax as indicated by IC 50 s within a clinically achievable range, MLL translocation status still had a significant effect on IC 50. MLL-AF4 + cases were least sensitive and MLL-ENL + cases were most sensitive to obatoclax. Respective IC 50 ranges across all 54 cases were: …
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Focusing to 30 nm for 19.5 keV has been demonstrated at APS beamlines with a WSi2/Si MLL having 728 layers made at the APS. These same techniques were used to achieve a partial linear zone plate structure having a 5-nm outer most zone width and consisting of 1588 total layers as discussed below.
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Abstract. MLL rearrangement is one of the key drivers and generally regarded as an independent poor prognostic marker in acute leukemias. The standard of care for MLL-rearranged (MLL-r) leukemias has remained largely unchanged for the past 50 years despite unsatisfying clinical outcomes, so there is an urgent need for novel therapeutic …
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Diode Violet Low Noise 400 nm Laser. Low noise version. of the above MDL-III-400 <1% noise MLL-III-400/ 1~300mW. Diode Violet 405nm Laser. 405 nm Violet laser. Near TEM00 beam. Power output 1~500mW. TTL and analog modulation. Power adjustable with. PSU-III-LED power supply MDL-III-405/ 1~500mW 405nm laser price. Diode Violet Low Noise …
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